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In a new study, we described the identification as well as the characterization of a whole new atypical opioid receptor with special negative regulatory Qualities towards opioid peptides.1 Our success confirmed that ACKR3/CXCR7, hitherto referred to as an atypical scavenger receptor for chemokines CXCL12 and CXCL11, can also be a wide-spectrum scav